"Salubrious" means something that is health-giving or healthful. The opposite, or antonym, is "Deleterious," which means causing harm or damage, often in a subtle or unexpected way.

"Doctrinaire" refers to someone who is rigidly attached to a particular doctrine or ideology. The opposite is "iconoclastic," meaning someone who challenges or overturns traditional beliefs or institutions.

Opposite Words: Pragmatic, Flexible, Practical, Adaptable.

"Panache" refers to flair, style, or confidence. The opposite is "drabness," meaning dullness, lack of color or excitement.

Opposite Words: Dullness, Plainness, Apathy, Blandness, Lackluster.

"Prolific" refers to being highly productive or fertile. The opposite is "barren," which means unproductive or incapable of producing.

Opposite Words: Barren, Unproductive, Sterile, Infertile, Meager.

"Immaculate" means perfectly clean or free from blemish. The opposite is "stained," which refers to something that is marked, soiled, or tainted.

Opposite Words: Spotted, Stained, Blemish, Splash, Defile, Smudge,

"Exile" refers to being banished or forced to leave one's homeland. The opposite is "repatriate," which means to return someone to their own country after they have been exiled.

Opposite Words: Repatriate, Recall, Welcome, Greet. 

"Idiosyncrasy" refers to a unique or peculiar characteristic or trait. The opposite is "commonplace," which refers to something ordinary or typical.

Opposite Words: Commonplace, Commonness, Normality, Conventionality.

"Culmination" refers to the highest point or peak of something. The opposite is "nadir," which refers to the lowest point or the most extreme point of adversity or failure.

Opposite Words: Abysmal, Nadir, Genesis, Base.

"Brusque" refers to a manner of speaking or acting that is curt or abrupt. The opposite is "diplomatic," meaning tactful, polite, and skillful in managing delicate situations.

Opposite Words: Diplomatic, Gracious, Mannerly, Urbane.

"Sanguine" refers to a hopeful or optimistic outlook. The opposite is "pessimism," which refers to a tendency to see the negative side of things, expecting the worst outcome.

Opposite Words: Pessimistic, Gloomy, Despondent, Bleak, Downcast